The draft assigned amateur baseball players to MLB teams.

In addition, compensation picks were distributed for players who did not sign from the 2017 MLB Draft and for teams who lose qualifying free agents.

[2] With a tie for the worst record in the 2017 MLB season at 64–98, the Detroit Tigers received the first overall pick ahead of the San Francisco Giants via a tiebreaker.

[3] The Detroit Tigers selected Casey Mize with the first overall pick in the draft.

On September 9, 2019, the Chicago Cubs promoted Nico Hoerner to the big leagues, making him the first player to reach MLB in this draft.