[1] As a senior in 2018, Weathers was the Gatorade National Baseball Player of the Year after going 11–0 with a 0.09 ERA and 148 strikeouts in 76 innings.

[6] He made his professional debut with the Arizona League Padres and was promoted to the Fort Wayne TinCaps in August.

He is the second pitcher and sixth player in MLB history to make his debut in the postseason, following Shane McClanahan, Alex Kirilloff, Adalberto Mondesi, Mark Kiger, and Bug Holliday.

[14] On July 24, Weathers hit his first career home run, a solo shot off Miami Marlins starter Braxton Garrett.

On August 1, 2023, Weathers was traded to the Miami Marlins in exchange for Garrett Cooper and Sean Reynolds.