The regular season began on June 12, 2018 with the opening ceremonies Smart Araneta Coliseum in Quezon City, and ended on March 11, 2019.
The league also held its first ever All-Star Game at the SM Mall of Asia Arena in Pasay on March 2, 2019.
The playoffs then began on March 12, 2019 and ended on April 25, 2019 when the San Juan Knights defeated the Davao Occidental Tigers in five games in the 2019 MPBL finals.
Teams still play a single round-robin tournament as part of the regular season, but the playoff format was changed to accommodate the new divisions.
To ensure that the league remains balanced, a new rule was added so that teams were limited to only one Filipino-foreigner per roster, that player must also not be taller than 6'4" (193 cm).
Both teams finished the season 20–5, but the Davao Occidental Tigers held the homecourt advantage for the finals, as they have defeated San Juan in their regular season matchup, but the San Juan Knights eventually won the championship in 5 games.
It was the inaugural edition of the MPBL All-Star Game, which took place at SM Mall of Asia Arena in Pasay.
The champions of these events are as follows: Most of the league's individual awards made their debut this season, which were given out before game 4 of the 2019 national finals at the Filoil Flying V Centre in San Juan.
Alongside the multitude of new awards, the league also began honoring its best players for each week of the regular season.
This season marked the second of three years of ABS-CBN's broadcasting rights of the league, as games were aired on S+A channel.