The 2018 South Florida Bulls football team represented the University of South Florida (USF) in the 2018 NCAA Division I FBS football season.

They played their home games at Raymond James Stadium in Tampa, Florida, and were led by second-year head coach Charlie Strong.

The Bulls competed as members of the East Division of the American Athletic Conference.

The 2018 Bulls became the first team in college football history to start a season 7–0 and lose their final six games.

One of the biggest storylines of the offseason was the addition of graduate transfer Blake Barnett who was named the starting quarterback following stints at Alabama and Arizona State.