The 2018 Southern Miss Golden Eagles football team represented the University of Southern Mississippi in the 2018 NCAA Division I FBS football season.

The Golden Eagles played their home games at the M. M. Roberts Stadium in Hattiesburg, Mississippi and competed in the West Division of Conference USA (C–USA).

They were led by third-year head coach Jay Hopson.

[3] Kicker Paker Shaunfield was selected as the preseason special teams player of the year.

Conference USA released their preseason media poll on July 17, 2018, with the Golden Eagles predicted to finish in fourth place in the West Division.