The 2018 UAB Blazers football team represented the University of Alabama at Birmingham (UAB) in the 2018 NCAA Division I FBS football season as a member of the West Division of Conference USA (C-USA).

They were led by third-year head coach Bill Clark and played their home games at Legion Field in Birmingham, Alabama.

They finished the season 11–3, 7–1 in C-USA play to be champions of the West Division.

On November 11, 2018, the Blazers made their first appearance in the Coaches' Poll at No.

Conference USA released their preseason media poll on July 17, 2018, with the Blazers predicted to finish in third place in the West Division.