2018 Thai League 4 Northeastern Region is the 10th season of the League competition since its establishment in 2009.

It is in the 4th tier of the Thai football league system.

Promoted from the 2017 Thailand Amateur League Northeastern Region Relegated to the 2018 Thailand Amateur League Northeastern Region (Sakon Nakhon Province Stadium) Updated to games played on 26 August 2018Source: Thai League 4 Source: Thai League 4 Note:Unk.1 Some error of T4 official match report 8 July 2018 (Mahasarakham 1–0 Mashare Chaiyaphum).

[12] Unk.2 Some error of T4 official match report 8 July 2018 (Khonkaen United 7–0 Ubon UMT United U-23).

[13] Unk.3 Some error of T4 official match report 1 August 2018 (Mahasarakham 0–0 Muang Loei United).