They played their home games at the Los Angeles Memorial Coliseum and competed as members of the South Division of the Pac-12 Conference.

15 in the AP Poll's preseason rankings, the Trojans finished the season 5–7, the program's first losing record since 2000 and missed a bowl game for the first time since that year (The 2010 and 2011 teams were banned from postseason play due to NCAA sanctions.)

On November 25, USC athletic director Lynn Swann announced that head coach Clay Helton would return in 2019 despite the disappointing season.

Quarterback Tailback Wide receiver Tight end Placekicker Offensive Lineman Defensive line Outside Linebacker Long snappers Inside Linebacker Cornerback Safety Punter Holder USC returns 31 starters in 2018, including 11 on offense, 13 on defense, and 5 on special teams.

Projecting Scholarship Distribution 2018 The official list of participants for the 2018 NFL Combine included USC football players WR Deontay Burnett, QB Sam Darnold, DE Rasheem Green, RB Ronald Jones II, WR Steven Mitchell Jr. & OLB Uchenna Nwosu.

Clay Helton (Head coach), Porter Gustin (OLB) & Cameron Smith (ILB) at Pac-12 media days.