Senator Ben Cardin was re-elected to a third and ultimately final term by a landslide margin of almost 35 points, the largest margin in any election for this seat since Maryland began holding direct elections for Senate in 1913.

[1] The incumbent, Ben Cardin, won the Democratic Party primary.

[2] Tony Campbell, a professor of political science at Towson University and former Army Chaplain, won the Republican Party primary.

[3][4] Businessman Neal Simon ran as an independent and Arvin Vohra was the Libertarian Party nominee in the general election.

With Republican governor Larry Logan winning re-election in the same year, this was the first election since 1974 in which Maryland simultaneously voted for a gubernatorial nominee and a U.S. Senate nominee of opposite parties.