The 2018 Uruguay Open was a professional tennis tournament played on clay courts.

It was the fourteenth edition of the tournament which was part of the 2018 ATP Challenger Tour.

It took place at the Carrasco Lawn Tennis Club in Montevideo, Uruguay between November 5 and 11, 2018.

The following players received wildcards into the singles main draw: The following player received entry into the singles main draw as an alternate: The following players received entry from the qualifying draw: