The cup winner is guaranteed a place in the 2019 AFC Champions League.
02/04/18 Nurafshon 1 - 3 Ithichor Sherdor 1 - 1 (aet; 7 - 6 p) Labsa The draw for the round of 32 was held on 28 February 2018.
[1] Lokomotiv, Nasaf, Pakhtakor and Bunyodkor received byes before the draw.
15/04/18 Lokomotiv BFK 0 - 4 Surkhon Khotira-79 0 - 1 (aet) Dinamo Samarqand Zaamin 2 - 3 (aet) Kokand-1912 Sherdor-Presstizh 3 - 2 Xorazm Mash'al 1 - 0 Istiklol Sogdiana 1 - 0 Metalourg AGMK 1 - 0 Norin Andijan 1 - 0 Navbahor 16/04/18 Aral Nukus 5 - 1 G'ijduvon Iftixor 1 - 0 Yozyovon Shortan 0 - 2 Neftchi Qizilqum 3 - 2 (aet) Buxoro The draw for the round of 16 was held on 18 April 2018.
The final was played on 28 October 2018 at the Istiqlol Stadium, Fergana.