This event featured a trilogy fight for the Glory Welterweight Championship between the champion Murthel Groenhart and Harut Grigorian as headliner.
The GLORY 50 SuperFight Series co-headline bout was originally scheduled to be a rematch between heavyweights Cătălin Moroșanu and Giannis Stoforidis.
The GLORY 52 co-main event bout was originally scheduled to be match between Lightweights Marat Grigorian and Stoyan Koprivlenski.
Robert Thomas suffered a concussion during training and was forced to withdraw from Glory Middleweight Contender Tournament.
Yousri Belgaroui and Jason Wilnis were originally scheduled to compete in the middleweight contender tournament, but instead squared off as part of Glory 53 SuperFight Series from Lille, France.
Jason Wilnis was forced to withdraw for medical reasons, Dawid Kasperski stepped in on a week's notice to take on Yousri Belgaroui.
Van Roosmalen had to withdraw due to a shoulder injury, Kiatmookao instead fought Kevin VanNostrand for the Glory Featherweight interim-title.
Glory welterweight champion Harut Grigorian was unable to compete due to acute gastroenteritis that has forced him from the fight card.
Vienot was scheduled to fight earlier in that evening, but has seized a short notice opportunity to headline opposite the former champion.
[4] On November 15, it was announced that Mohammed Jaraya had suffered a hand injury and was pulling out of his bout with Robbie Hageman.