The 2019 AFC Champions League knockout stage was played from 18 June to 24 November 2019.
Each tie is played on a home-and-away two-legged basis.
The away goals rule, extra time (away goals do not apply in extra time) and penalty shoot-out were used to decide the winner if necessary (Regulations Article 11.3).
[1] Up to the semi-finals, matches in the West Region were played on Mondays and Tuesdays, while matches in the East Region were played on Tuesdays and Wednesdays.
The bracket was decided after the draw for the quarter-finals, which was held on 2 July 2019, 16:00 MYT (UTC+8), at the AFC House in Kuala Lumpur, Malaysia.
[4] In the quarter-finals, the four round of 16 winners from the West Region (whose identity was not known at the time of the draw) played in two ties, and the four round of 16 winners from the East Region played in two ties, with the matchups and order of legs decided by draw, without any seeding or country protection.
In the final, the two semi-final winners played each other, with the order of legs (first leg hosted by team from the West Region, second leg hosted by team from the East Region) reversed from the previous season's final.