The 2019 Advantage Cars Prague Open, also known as Advantage Cars Prague Open by Moneta Money Bank for sponsorship reasons, was a professional tennis tournament played on outdoor clay courts.

It was the 26nd (men) and 15th (women) editions of the tournament which was part of the 2019 ATP Challenger Tour and the 2019 ITF Women's World Tennis Tour.

It took place in Prague, Czech Republic between 22 and 28 July 2019.

[1] The following players received wildcards into the singles main draw: The following player received entry into the singles main draw as an alternate: The following players received entry into the singles main draw using their ITF World Tennis Ranking: The following players received entry from the qualifying draw: The following players received wildcards into the singles main draw: The following player received entry as a special exempt: The following players received entry from the qualifying draw: The following players received entry to the draw as Lucky Losers: