The 2019 Chicago White Sox season was the club's 120th season in Chicago and 119th in the American League.

The Sox played their home games at Guaranteed Rate Field.

It was the final season of gameday broadcasts on WGN-TV, bringing to a close an era of periodic White Sox free-to-air broadcasts to its fans all over the city, as beginning in 2020 the White Sox will broadcast almost all its home and away games on both NBC Sports Chicago and NBC Sports Chicago+.

Although they improved on their 62–100 record from the previous season, they missed the playoffs for the 11th straight year.

Infielders Coaches Note: G = Games played; AB = At bats; R = Runs; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; SB = Stolen bases; BB = Walks; AVG = Batting average; SLG = Slugging average Source:[1] Note: W = Wins; L = Losses; ERA = Earned run average; G = Games pitched; GS = Games started; SV = Saves; IP = Innings pitched; H = Hits allowed; R = Runs allowed; ER = Earned runs allowed; BB = Walks; SO = Strikeouts Source:[2]