The Tigers competed as members of the Atlantic Coast Conference (ACC), and played their home games at Memorial Stadium in Clemson, South Carolina.

Entering the season as defending national champions, Clemson began the year ranked first in the polls.

Despite securing another undefeated regular season and its fifth consecutive conference title after defeating Virginia in the ACC Championship Game, Clemson fell to third in the final College Football Playoff rankings of the season, owing to its comparatively weak strength of schedule.

They were selected to the Fiesta Bowl to play second-seeded Ohio State, where the Tigers won by a score of 29–23.

Offensive lineman John Simpson was named a consensus All-American, and he was joined on the first-team All-ACC by Lawrence, Etienne, wide receiver Tee Higgins, and offensive lineman Tremayne Anchrum.

Clemson's 2019 recruiting class consisted of 29 signees, including 17 that enrolled early and one that grayshirted.

[30] Quarterback Running back Wide receiver Tight end Placekicker Offensive lineman Defensive lineman Punter Linebacker Defensive back Long snappers Source:[31]