Led by first-year head coach Mel Tucker, the Buffaloes played their home games on campus at Folsom Field in Boulder and finished at 5–7 (3–6 in Pac-12, fifth in the South Division).

Previously the defensive coordinator at Georgia, Tucker left after just one season at CU for Michigan State of the Big Ten Conference.

In the 2019 Pac-12 preseason media poll, Colorado was voted to finish in last place in the South Division.

In Pac-12 Conference play, Colorado will play the other members of the South Division and draws Oregon, Stanford, Washington, and Washington State from the North Division.

They will not play California or Oregon State as part of the regular season.