The 2019 Holy Cross Crusaders football team represented the College of the Holy Cross as a member of the Patriot League during the 2019 NCAA Division I FCS football season.

Led by second-year head coach Bob Chesney, Holy Cross compiled an overall record of 7–6 with a mark of 5–1 in conference play, winning the Patriot League title.

The Crusaders advanced to the NCAA Division I Football Championship playoffs, where they lost in the first round to Monmouth.

[1] The Crusaders had three players selected to the preseason All-Patriot League team.

The Crusaders received an automatic bid (due to winning their conference) for the postseason tournament, with a first-round pairing against Monmouth.