Francisco "Isko Moreno" Domagoso won the elections, enabling him to serve a three-year term as the mayor of Manila.

Manuel Luis "Manny" Lopez (NPC, supported by PDP-Laban and KKK) is the incumbent, and he will face former representative Benjamin "Atong" Asilo to contest a second term.

His cousin Alex is running under the Nacionalista Party, with support from PMP and KABAKA; Carlo is a member of PDP-Laban.

John Marvin "Yul Servo" Nieto is the incumbent, and was running under the PDP-Laban banner with support from Asenso Manileño.

Edward Maceda is the incumbent and ran against former representative Maria Theresa "Trisha" Bonoan-David (NUP, supported by Asenso Manileño) and independent candidate barangay kagawad Christopher "Chris" Gabriel.

Yvette registered as a candidate under Bagumbayan-VNP (supported by PDP-Laban and Alfredo Lim's KKK Party) and prior to her candidacy had been appointed by President Rodrigo Duterte as chair of the Nayong Pilipino Foundation.

Ocampo's arch-rival, former representative Bienvenido "Benny" Abante, is also running under Asenso Manileño, as well as incumbent City Councilor and fiscal Casimiro Sison under Pwersa ng Masang Pilipino's Team Legacy.