The 2019 NCAA Division II women's basketball tournament involved 64 teams playing in a single-elimination tournament to determine the NCAA Division II women's college basketball national champion.

The first three rounds were hosted by top-seeded teams in regional play.

The eight regional winners met for the quarterfinal and semifinals, better known as the "Elite Eight" and "Final Four" respectively, and National Championship game at Alumni Hall in Columbus, Ohio.

[1] In the title game, Lubbock Christian defeated Southwestern Oklahoma State in double overtime to win their second Division II championship.

[2] * – Denotes overtime period * – Denotes overtime period * – Denotes overtime period Quarterfinals, semifinals and finals were hosted at Alumni Hall in Columbus, Ohio.