The Clayton State Lakers are the athletic teams that represent Clayton State University, located in Morrow, Georgia, in intercollegiate sports at the Division II level of the National Collegiate Athletic Association (NCAA), primarily competing in the Peach Belt Conference since the 1995–96 academic year.

Clayton State competes in eleven intercollegiate varsity sports.

Men's sports include basketball, cross country, soccer, and track and field (both indoor and outdoor); while women's sports include basketball, cross country, soccer, and track and field (both indoor and outdoor).

Clayton State University won its first national championship in school history when the Lakers won the NCAA Division II women's basketball national title in 2011.

It is still the only women's basketball championship won by a team from the Southeast Region.