The 2019 NCAA Division I Softball season, play of college softball in the United States organized by the National Collegiate Athletic Association (NCAA) at the Division I level, began February 7, 2019.

The Women's College World Series, consisting of the eight remaining teams in the NCAA Tournament will be held annually in Oklahoma City, Oklahoma at ASA Hall of Fame Stadium, will end in June 2019.

The teams in each conference that win their regular season title are given the number one seed in each tournament.

UTA Mavericks defeated the Iowa State Cyclones in the championship; Aileen Garcia was named MVP for the series.

[72] Batting Pitching NCAA Division I season perfect games: 5 – Nicole Newman, Drake Bulldogs[73] Freshman class single game strikeouts: 27 – Kelly Nelson, Holy Cross Crusaders; March 6, 2019 (16 innings) Team consecutive wins streak: 41 – Oklahoma Sooners; February 24-May 19, 2019 The following players were members of the All-American Teams.