Shortly before the game started, the team added their star outfielder Giancarlo Stanton and third baseman Miguel Andújar to an already filled up injury list.

[17] The remaining Yankees defeated the Tigers, majorly thanks to a stellar diving catch by Aaron Judge in the eighth inning, when they were in jeopardy of losing their shy lead.

On April 2, with the game tied at 1 in the top of the ninth inning, Dustin Peterson's double gave the Tigers the lead against the Yankees closer Aroldis Chapman, in what was the first hit of his career.

[19] In the final game of the series, the Yankees lost 2–1 to a dominating performance by left-handed pitcher Matthew Boyd, who struck out a career-high 13 batters in 6+1⁄3 innings.

[20] Yankees lost the series 1–2 (5–6 runs) New York swept the Orioles at Camden Yards in their second meeting of the season, delivering a total of 14 home runs—seven of which in the last game alone.

Gary Sánchez homered thrice and had the opportunity for a fourth home run, a rare feat only accomplished by eighteen players in MLB to date.

In the 8th inning of game 1, Carlos Correa hit off Adam Ottavino, who had not allowed a run yet in the season, to give Houston what would be the definitive lead, 4–3.

[25] The next day, the Yankees announced pitcher Luis Severino had strained a right latissimus dorsi muscle and would not return to the mound until about late June, another addition to the Yanks million-dollar worth injured list.

Onto that day's game, a mistake by Brett Gardner in the third inning, who stopped running to first base assuming the ball had been foul, allowed a double play by the Astros.

Moreover, Clint Frazier missed multiple diving catches, and relief pitcher Chad Green allowed a two-run double to George Springer in the eight inning.

Having cut the deficit from 2–7 to 6–7 in the top of the eighth, a bad throw by Gleyber Torres fostered an Astros run to seal the game and the series.

The first game was an 8–0 shutout by the Yankees, with a dominating James Paxton who struck out 12 Red Sox batters and allowed only two hits over eight innings.

However, a Brett Gardner go-ahead grand slam in the bottom seventh, which was his 100th career home run, gave the Yanks the definitive lead, 5–3.

Hale pitched for four innings and allowed two runs, and was relieved by Adam Ottavino in the sixth, Tommy Kahnle in the seventh, Zack Britton in the eighth, and Aroldis Chapman got his 15th save of the season in the ninth.

Home runs by Clint Frazier, Brett Gardner and Gary Sánchez steampowered a 5–2 Yankees win, improving to a 3–0 record with Green as a starter.

In the series opener, the Red Sox got onto the scoreboard first, but DJ LeMahieu later delivered an RBI double and a home run off Chris Sale to secure a 4–1 Yankees win.

A. Happ limiting the Sox to a single homer over five innings and closer Aroldis Chapman striking out two of three men to earn his 16th save of the season.

[36] On the next day, with the score tied at 3 in the bottom fifth, Gary Sánchez hit a two-run homer to get the lead, which was locked down by six Yankees relief pitchers throwing a combined 5+1⁄3 scoreless innings.

In the series opener, a dominant Masahiro Tanaka pitched his seventh complete game in the Major League, allowing only two hits and striking 10 batters in a 3–0 shutout.

New York's offense contributed with two six-run explosive first and seventh innings, which added up to a 12–1 blowout, capped by Gleyber Torres' first career grand slam.

Second baseman DJ LeMahieu and catcher Gary Sánchez were both on the AL starting lineup, Masahiro Tanaka was the winning pitcher, and Aroldis Chapman made the save.

The Yankees started the series with a 5–4 loss, as Aroldis Chapman blew the save and allowed a three-run homer with two outs in the top of the ninth.

In the bottom eighth, with the Yankees trailing 3–2, an Aaron Judge two-run homer sparked a rally to even the series, capped by Didi Gregorius' fourth career grand slam.

[47] The Yankees took the series in the second header, with a 5–1 win in which Chad Green, Nestor Cortes and Luis Cessa combined to limit the Rays to one run and five hits over 7+2⁄3 frames.

The Yankees completed a four-game sweep of the Red Sox for the first time since August 2009, reaching a season high 33 games over .500 while putting their division rivals in jeopardy of missing the postseason.

The Yanks started the series by winning their sixth game in a row, 9–6, while setting an MLB record for the most home runs delivered in an away ballpark in a season, at 32.

The Yankees claimed the series 2–1, something that would give them home-field advantage in the Fall Classic in case both teams finish with the same winning percentage in the regular season.

[54] One of these homers was the 100th of Aaron Judge's career, who became the third fastest player in baseball history to reach the centennial mark, during the 7–0 shutout by Masahiro Tanaka in the second game of the series.

Trailing 4–0 and with six outs left, the Yankees cut their deficit to 4–3 in the bottom eighth, and then Brett Gardner and pinch-hitter Mike Ford back-to-back homered off Liam Hendriks in the ninth to tie the score and win the game, respectively.

In the last game, the second of a doubleheader on September 12, New York previewed what could be one of their postseason strategies: starting CC Sabathia, who struck out five in 3+1⁄3 innings to surpass John Smoltz on the all-time strikeouts list, and then relieving him with Domingo Germán, who did not allow a run over four frames, in a 6–4 victory.