The team was led by Mark Farley in his 19th season and played their home games in the UNI-Dome in Cedar Falls, Iowa as a member of the Missouri Valley Football Conference.

They received an at-large bid to the FCS Playoffs where they defeated San Diego and South Dakota State to advance to the quarterfinals where they lost to James Madison.

In the MVFC preseason poll released on July 29, 2019, the Panthers were predicted to finish in fifth place.

[2] Offense Briley Moore – TE Jackson Scott-Brown – OL Defense Xavior Williams – DB

[3][4] The Panthers were selected for the postseason tournament, with a first-round pairing against San Diego.