The Bulls were led by third-year head coach Charlie Strong and played their home games at Raymond James Stadium in Tampa, Florida.

They competed as members of the East Division of the American Athletic Conference.

In January 2019, South Florida hired Kerwin Bell as their new offensive coordinator, replacing Sterlin Gilbert, who left to take the head coaching job at McNeese State.

Bell had spent the previous three seasons as the head coach at Valdosta State, where he led the school to an NCAA Division II national title in 2018.

Their fourth non-conference game will be played at home against BYU, a football independent, after the start of the conference schedule.