The 2019 Texas Southern Tigers football team represented Texas Southern University a member of the West Division of the Southwestern Athletic Conference (SWAC) during the 2019 NCAA Division I FCS football season.

Led first-year head coach Clarence McKinney, the Tigers compiled an overall record of 0–11 with a mark of 0–7 in conference play, placing last out of five teams in the SWAC's West Division.

Texas Southern played home games at BBVA Compass Stadium in Houston.

The Tigers were picked to finish in fourth place in the West Division.

at Gayle and Tom Benson Stadium, San Antonio, TX