The Hokies were led by fourth-year head coach Justin Fuente and played their home games at Lane Stadium in Blacksburg, Virginia.

In the preseason ACC media poll, Virginia Tech was predicted to finish in third in the Coastal Division.

[1] In non-conference play, Virginia Tech played home games against Old Dominion of Conference USA, Furman of the Southern Conference, and Rhode Island of the Colonial Athletic Association, as well as a road game against Notre Dame, a football independent.

After poor performances against USC and Michigan, Notre Dame stepped up defensively against Virginia Tech.

[4] Since the start of the 2016 season, during the week before each game, Head Coach Justin Fuente selects an outstanding player to wear the #25 jersey in honor of former head coach, Frank Beamer, who wore #25 as a player for Virginia Tech.