The 201st Anti-aircraft Missile Brigade "Hetman Pylyp Orlyk" is a brigade of the Ukrainian Air Force tasked with air defense operations throughout Mykolaiv Oblast.

It operates S-300B1 and S-300PS missile systems and is subordinated to the Air Command South.

In 1992, after the Dissolution of the Soviet union, the 201st brigade took an oath of loyalty to the Ukrainian people.

On 4 December 2019, the brigade was awarded the honorary name of Hetman "Pylyp Orlyk".

[1] At the beginning of January 2022, the S-300 PS anti-aircraft missile systems of the brigade were redeployed from ATO zone to take over the combat duty to protect the airspace of the southern Ukraine.