The Hearts of Oak won the domestic double, the league and the FA Cup.

[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

The season was delayed as a result of COVID-19 pandemic in Ghana, causing the team to start preparations in September 2021.

[4][5] Hearts however pitched camp at the Glow-Lamp Soccer Academy owned by Nii Odartey Lamptey in Elmina for two weeks between 29 October 2020 to 12 November 2020.

They were set to play Medeama SC, however the fixture was replaced with one against Proud United.