The 2020–21 Adelaide Strikers Women's season was the sixth in the team's history.

Coached by Luke Williams and captained by Suzie Bates, the Strikers played the entirety of WBBL|06 in a bio-secure Sydney hub due to the COVID-19 pandemic.

[1] They finished the regular season in sixth place, missing out on qualifying for the finals.

Marquees are classed as any overseas player, or a local player who holds a Cricket Australia national contract at the start of the WBBL|06 signing period.

[2] Personnel changes made ahead of, and during, the season included: The table below lists the Strikers players and their key stats (including runs scored, batting strike rate, wickets taken, economy rate, catches and stumpings) for the season.