The 2020–21 Hawaii Rainbow Wahine basketball team represented the University of Hawaii at Manoa during the 2020–21 NCAA Division I women's basketball season.

The Rainbow Wahine, led by ninth-year head coach Laura Beeman, played their home games at the Stan Sheriff Center in Honolulu, Hawaii.

The Rainbow Wahine finished the 2019–20 season 15–17 (10–6 in Big West play), to finish fourth in the Big West standings.

They defeated Cal State Fullerton in the first round of the Big West Conference tournament, 72–59.

[1] They did not play any other games beyond that as the tournament was canceled due to the COVID-19 pandemic.