The 2020–21 Missouri Tigers women's basketball team represented the University of Missouri during the 2020–21 NCAA Division I women's basketball season.

The Tigers, led by eleventh-year head coach Robin Pingeton, played their home games at Mizzou Arena and competed as members of the Southeastern Conference (SEC).

Missouri finished the season 9–13 (5–9 SEC) and received an at-large bid to the 2021 WNIT, where they lost in the first round and a consolation game.

The SEC media poll was released on November 17, 2020, with the Tigers selected to finish in tenth place in the SEC.

[1] The Tigers had one player selected to the preseason all-SEC teams.