The 2020–21 Mississippi State Bulldogs women's basketball team represented Mississippi State University during the 2020–21 NCAA Division I women's basketball season.

The Bulldogs, led by first-year head coach Nikki McCray-Penson, played their home games at Humphrey Coliseum and competed as members of the Southeastern Conference (SEC).

The Bulldogs lost to South Carolina in the Championship of the SEC tournament.

Old Dominion head coach Nikki McCray-Penson was hired to replace him.

[3] The Bulldogs had two players selected to the preseason all-SEC teams.