The 2020–21 Ohio State Buckeyes women's basketball team represented the Ohio State University during the 2020–21 NCAA Division I women's basketball season.

The Buckeyes, led by eighth year head coach Kevin McGuff, played their home games at Value City Arena and the Covelli Center.

They did not participate in the Big Ten women's basketball tournament, NCAA tournament or the WNIT due to a self-imposed postseason ban.

As the sixth seed in the Big Ten women's basketball tournament the defeated Minnesota, Iowa, and Michigan before losing to Maryland in the finals.

They did not get a chance for further post season play, as the NCAA women's basketball tournament and WNIT were cancelled before they began due to the COVID-19 pandemic.