City rivals Manchester United finished not far behind them, despite not really being in the title race for much of the season, a consequence of a poor start which included three home losses in their opening six games (with further losses to Sheffield United, Leicester City and Liverpool at the turn of the year); however, the Red Devils at least ensured Champions League football once again, thanks in part to a remarkable run of form that saw them go unbeaten away from home all season.
The battle for the last two Champions League spots ended up going to the final day, with Chelsea, Leicester City and Liverpool battling it out – remarkably taking third spot were Liverpool, whose first title defence since 1990 ended up being one of struggle; whilst the Merseyside club stood top at the end of 2020, a complete collapse in form in the new year saw both the team's hopes of retaining the title as well as their 68-game unbeaten run at Anfield practically implode under the weight of both a lack of fans and an extensive injury crisis, including a season-ending injury to star defender Virgil van Dijk just five games into the campaign – however, a strong late run of form, coupled with the teams above them dropping points, helped the Reds to close the gap and squeeze into the top four.
Chelsea finished fourth, a strong second half of the season under new manager Thomas Tuchel pushing the Blues from as low as ninth near the end of January to both securing a Champions League spot again and winning their first Champions League final since 2012 with victory over Manchester City, ending a mixed season (which included a second consecutive FA Cup final loss in a row) on a high.
Despite achieving some superb results, including taking four points off city rivals Liverpool in two controversial Merseyside derby games, Everton's hopes of European football were let down by a poor run of form on their home ground, securing just six wins compared to eleven on the road, ending their season in a disappointing tenth.
Finishing second were Watford, who overcame yet another mid-season managerial change (their sixth in just over a year) to join the Canaries in returning to the top-flight after one season, a superb run of form in 2021 earning Spanish head coach Xisco Munoz promotion on top of the Hornets also having their own impressive defence, conceding the least number of goals for any second-tier team since losing play-off finalists Preston North End in 2006.
Taking the final spot through the playoffs by beating Swansea City - and ending a barren run of nine playoff campaigns across their history without success - were Brentford, who made amends for their narrow final loss the previous year and secured promotion to the Premier League for the first time, their win also sending the Bees back into the top-flight for the first time in 74 years; in addition, in a first for English football, all three promoted managers from any of the Football League divisions came from outside the British Isles.
Despite ultimately losing out in the playoff semi-finals, Barnsley were undoubtedly the surprise package of the campaign; having looked likely to battle relegation yet again at the end of October and then seeing their head coach depart for America, the appointment of unknown French manager Valérien Ismaël saw the Tykes rocket up the table - with some impressive results along the way to boot - and comfortably secure 5th place.
For the second reason running, the battle to avoid relegation saw all three places left wide open going into the last round of games – taking bottom place in the closing minutes of the season were Sheffield Wednesday, who fought valiantly to avoid the drop, only for the points deduction (twelve later reduced to six on appeal) for breaching financial rules imposed prior to the start of the season result in survival falling out of their reach, sending the Yorkshire club back into the third tier after a nine-year absence.
Swindon Town's season rapidly fell apart after promotion-winning manager Richie Wellens moved to Salford City early in the campaign, finishing the season with both the most defeats and the worst defence in the division as they suffered immediate relegation back to League Two; fellow newly promoted side Northampton Town joined them in immediate relegation, ultimately being cost dear by a terrible run of form in the winter.
Finishing just above them were Southend United, who suffered their second consecutive relegation and fell out of the Football League for the first time in their history, a run of just one win in their opening 15 games on top of an inability to score (their total of 29 goals being the lowest scored by anyone in a 24-team division since 1982) ended up setting the tone for the Essex club's hopes and in similar circumstances to Grimsby, the return of former manager Phil Brown late in the season proved to be too late to save the Shrimpers from losing their 101-year Football League status.