[2] UANL defeated Los Angeles FC in the final to win their first CONCACAF club title.

As the winners of the 2020 CONCACAF Champions League, they qualified for the 2020 FIFA Club World Cup in Qatar.

On 12 March 2020, CONCACAF suspended the tournament with immediate effect due to the COVID-19 pandemic.

[4] On 2 November 2020, it was announced that the tournament would resume at a centralized location in the United States from 15 to 22 December 2020, with the sole quarter-final to have not completed a first leg, semi-finals, and final played as single-leg matches.

[5] On 10 November, Exploria Stadium in Orlando, Florida, United States was designated as the host for the remainder of the tournament, which consisted of seven matches, including the quarter-finals, semi-finals, and final.

For the United States, four teams qualified for the CONCACAF Champions League, three through the Major League Soccer (MLS) season and one through its domestic cup competition: If there was any team which qualified through multiple berths, or if there was any Canada-based MLS team which were champions of the MLS Cup, the Supporters' Shield, or conference regular season, the vacated berth was reallocated to the U.S.-based team with the best MLS regular season record not yet qualified.

In the following table, the number of appearances, last appearance, and previous best result count only those in the CONCACAF Champions League era starting from 2008–09 (not counting those in the era of the Champions' Cup from 1962 to 2008).

The draw for the 2020 CONCACAF Champions League was held on 9 December 2019, 21:00 EST (local time 20:00 CST), at the University of the Cloister of Sor Juana in Mexico City, Mexico.

[12] The CONCACAF Club Index, instead of ranking each team, was based on the on-field performance of the teams that had occupied the respective qualifying slots in the previous five editions of the CONCACAF Champions League.

To determine the total points awarded to a slot in any single edition of the CONCACAF Champions League, CONCACAF used the following formula: The slots were assigned by the following rules:[13] The 16 teams were distributed in the pots as follows:[14][15] In the CONCACAF Champions League, the 16 teams played a single-elimination tournament.

[21] Following resumption of the tournament, the second legs were played at Exploria Stadium in Orlando from 15–16 December 2020.

Following resumption of the tournament, the semi-finals were played at Exploria Stadium in Orlando on 19 December 2020 as single-leg matches.

Following resumption of the tournament, the final was played at Exploria Stadium in Orlando on 22 December 2020 as a single-leg match.