The 2020 Cal Poly Mustangs football team represented California Polytechnic State University, San Luis Obispo as member of the Big Sky Conference during the 2020–21 NCAA Division I FCS football season.
Led by first-year head coach Beau Baldwin, the Mustangs compiled an overall record of 0–3 with an identical mark in conference play, placing eighth in the Big Sky.
Cal poly played home games at Mustang Stadium in San Luis Obispo, California.
On March 29, 2021, Cal Poly announced that the team would opt out of the remainder of the 2021 spring season, citing safety issues related to the COVID-19 pandemic and numerous injuries to players.
[3] The Mustangs had games scheduled against California and San Diego, which were later canceled before the start of the 2020 season.