The Tigers competed as a member of the Atlantic Coast Conference (ACC) and played their home games at Memorial Stadium in Clemson, South Carolina.

Precautions were taken to reduce the spread of the virus, including testing, isolation requirements, and limitations on the number of fans in attendance.

Clemson began the year ranked first in the preseason AP Poll, and handily won their first seven games of the season, including a 42–17 win over then-No.

Starting quarterback Trevor Lawrence tested positive for COVID-19 on October 29, and was forced to miss the team's next two games against Boston College and temporary ACC member Notre Dame.

In the rematch against the Fighting Irish, this time with Lawrence at quarterback, the Tigers were victorious by a score of 34–10, to win their sixth consecutive ACC title.

The team's leading rusher was Travis Etienne, who was named a consensus All-American all-purpose back.

On defense, the team featured two first-team all-conference members in lineman Bryan Bresee and cornerback Derion Kendrick.

[2] Sources: Listed in the order that they were released Clemson had games scheduled against Akron and South Carolina, which were both canceled due to the COVID-19 pandemic.