[4] In October 2020, The Washington Post identified this state election as one of eight whose outcomes could affect partisan balance during post-census redistricting.

Seats where the margin of victory was under 10%: In the 1st district Democratic incumbent Tenisha Yancey won her primary unopposed on August 4.

On November 3, Yancey defeated the Republican nominee, Latricia Ann Lanier, in the general election.

He won his primary election, beating challengers Ivy Nichole Neal and David Palmer.

On November 3, Young defeated Republican nominee Miroslawa Teresa Gorak in the general election.

[26] In the 10th district, incumbent Democrat Leslie Love was unable to run for re-election due to term limits.

[29] In the 13th district, incumbent Democrat Frank Liberati was unable to run for re-election due to term limits.

[36] In the 38th district, incumbent Republican Kathy Crawford was prevented from running for re-election due to term limits.

[44] On September 18, 2020, the Michigan Republican Party pointed to May's criminal record, which included conviction for robbery, possession of cocaine, and retail fraud.

The state Republican Party criticized the Michigan Education Association for endorsing him, despite his criminal past.

He confirmed that they were true, but also claimed that he had made significant improvements to his life since his convictions, and that through his work as a clinician, has been able to help those who had been in a similar position to himself.

[43] Incumbent Republican Brandt Iden was term limited, which made the 61st district an open seat.

[54] In the 104th district, incumbent Republican Larry Inman did not run for re-election due to term limits.