The Tigers played their home games at Faurot Field in Columbia, Missouri, and competed in the Eastern Division of the Southeastern Conference (SEC).

In a season impacted by the COVID-19 pandemic, the Tigers compiled a 5–5 record, all in conference games.

The team was set to face Iowa in the Music City Bowl, but had to withdraw due to COVID-19 issues.

[1] Listed in the order that they were released In the preseason media poll, Missouri was predicted to finish in sixth place in the East Division.

[2] Roster Last update: October 11, 2020 Missouri had games scheduled against BYU, Central Arkansas, Eastern Michigan, and Louisiana, which were all canceled due to the COVID-19 pandemic.