Miami FC, the defending league champions, left in the off-season and joined the National Independent Soccer Association and later the USL Championship.
[3] It would include new teams, mostly from the Gulf Coast Premier League, Jacksonville Armada U-23 from the Sunshine Conference, and the returning New Orleans Jesters.
Only two of the three West Region conferences had begun play prior to the season being cancelled.
[9] Pittsburgh won the "Rust Belt Group" on July 29 with a win over the Commodores.
[10] In addition, the July 29 match between Buffalo and Cleveland also served as a group stage game for the 2020 NISA Independent Cup, which both teams were also taking part in alongside former NPSL member Detroit City FC in that tournament's "Great Lakes Region".