In October 2020, The Washington Post identified this state election as one of eight whose outcomes could affect partisan balance during post-census redistricting.

Democrats selected business owner Phil Heasley as their nominee, while Republicans nominated attorney Timothy R.

Democrats selected former Smithton mayor Robert Prah Jr. as their nominee, while Republicans nominated union carpenter Eric Davanzo.

[15] A special election for the 190th legislative district was held on February 25 to fill Johnson-Harrell's vacancy.

Democrats selected local SEIU business agent G. Roni Green as their nominee, and Republicans nominated businesswoman Wanda Logan.