The 2020 Saint Louis FC season was the club's sixth and final season of existence, and their sixth consecutive season in the USL Championship, the second tier of American soccer.

Saint Louis additionally competed in the U.S. Open Cup.

This article covers the period from November 18, 2019, the day after the 2019 USLC Playoff Final, to the conclusion of the 2020 USLC Playoff Final, scheduled for November 12–16, 2020.

[1] As a USL Championship club, St. Louis FC will enter the competition in the Second Round, to be played April 7–9.

[3]