Additionally, Amendment A required the South Dakota State Legislature to establish a medical marijuana program and legal hemp sales by April 1, 2022.

[1] On February 8, 2021, Amendment A was struck down as unconstitutional by Judge Christina Klinger on the grounds that it violated the state's single-subject rule for ballot initiatives.

On November 20, 2020, a lawsuit was filed by Pennington County Sheriff Kevin Thom and South Dakota Highway Patrol Superintendent Rick Miller seeking to have Amendment A invalidated.

The plaintiffs argued that the initiative violated the state's single-subject ballot measure provision and was a "revision" (which would require a constitutional convention) rather than an amendment.

[4] Public reaction to the lawsuit was negative and the Pennington County Sheriff Office's Facebook page was review bombed shortly after it was filed.