Incumbent Republican Senator Lindsey Graham won re-election for a fourth term and defeated Democratic nominee Jaime Harrison.

[1] Despite forecasting throughout the last few months of the race showing a very close race as well as Harrison having record fundraising numbers, Graham defeated Harrison by 54.4% to 44.2% and a margin of 10.2% in the November 3, 2020 general election.

Harrison slightly outperformed Democratic nominee Joe Biden in the concurrent presidential election, who lost to President Donald Trump by 11.7% in South Carolina.

Representatives Governors Former governors State officials Local officials Individuals Organizations Jaime Harrison ran a number of ads attempting to attract conservative voters from Lindsey Graham by elevating Constitution Party candidate Bill Bledsoe as "too conservative—but in doing so, the would-be attack ad offers up right-wing voters a laundry list of things to like about him".

[107] Meanwhile, Graham ran ads attempting to brand Harrison as a diehard liberal while connecting him with Nancy Pelosi and Chuck Schumer.