The 2020 Vuelta a Guatemala was a road cycling stage race that took place in Guatemala between 23 October and 1 November 2020.

The race was rated as a 2.2 event as part of the 2020 UCI America Tour, and was the 60th edition of the Vuelta a Guatemala.

[1] Two UCI Continental teams, one national team, and eleven domestic teams make up the fourteen teams that participated in the race.

Only three of those teams did not enter the maximum of six riders; ASO Quetzaltenalgo-C.Castelli, Canel's–Zerouno, and Decorabaños each entered five.

This meant that 81 riders started the race, of which 61 finished.