Esquipulas Palo Gordo (Spanish pronunciation: [eskiˈpulas ˈpalo ˈɣoɾðo]) is a town and municipality in the San Marcos department of Guatemala.

The main agricultural products are: sugar cane, corn, wheat, potato, and beans; the land is flat and fertile.

The municipality celebrates its annual fair in honor of the Black Christ of Esquipulas between January 12 and 17.

In 2011, a woman joined the mayoral race in Esquipulas Palo Gordo for the very first time, when Edilma Marleny Ochoa Barrios ran for Unión del Cambio Nacional —UCN—.

Esquipulas Palo Gordo can be reached two ways: It is surrounded by San Marcos Department municipalities: