The 2021–22 Adelaide Strikers Women's season was the seventh in the team's history.

Coached by Luke Williams and captained by Tahlia McGrath, the Strikers ended the regular season of WBBL|07 in fourth place, qualifying for the knockout stage of the tournament.

[1] They proceeded to defeat the Brisbane Heat and the Melbourne Renegades in sudden death encounters to book a place in the Final against the Perth Scorchers at Perth Stadium on 27 November 2021.

[2] In the championship decider, the Strikers were defeated by 12 runs, resulting in their second runners-up finish in three seasons.

[4] Personnel changes made ahead of the season included: Squad details during the season included: The table below lists the Strikers players and their key stats (including runs scored, batting strike rate, wickets taken, economy rate, catches and stumpings) for the season.