The 2021–22 American Eagles men's basketball team represented American University in the 2021–22 NCAA Division I men's basketball season.

The Eagles, led by eighth-year head coach Mike Brennan, played their home games at Bender Arena in Washington, D.C. as members of the Patriot League.

10 seed in the Patriot League tournament, they defeated Holy Cross in the first round[2] before losing to Navy in the quarterfinals.

[3] In a season limited due to the ongoing COVID-19 pandemic, the Eagles finished the 2020–21 season 4–6, 4–5 in Patriot League play, to finish in second place in the South division.

5 seed in the Patriot League tournament, they lost to Army in the quarterfinals.