This was the first season under newly hired head coach Matthew Otten, who came over from Yoast United.
In the regular season, Donar failed to advance after taking big losses against London Lions and Medi Bayreuth.
In early November, two new foreign players were signed in Donte Thomas and Jimmy Gavin.
Donar ended the year 2021 with two losses against ZZ Leiden and Yoast United.
On 20 March 2022, Donar won its seventh national Basketball Cup after defeating Heroes Den Bosch in the final, which was played in the MartiniPlaza.